Table 3 Multivariate logistic regression analysis of current gastrointestinal problems by age, gender and mutation group (n = 164)

Age group

 0 to <5 years

50 (40.0)

baseline

–

52 (40.3)

baseline

–

48 (41.4)

baseline

–

44 (40.0)

baseline

–

 5 to < 10 years

42 (33.6)

2.03 (0.83,4.94)

0.12

42 (32.6)

2.12 (0.90,5.00)

0.08

36 (31.0)

1.07 (0.42,2.72)

0.88

37 (33.6)

1.35 (0.37,4.86)

0.65

 10 years or older

33 (26.4)

3.5 (1.22,10.08)

0.02

35 (27.1)

2.78 (1.14,6.74)

0.02

32 (27.6)

2.24 (0.88,5.71)

0.09

29 (26.4)

7.48 (1.96,28.53)

0.003

Gender

 Female

112 (89.6)

baseline

–

115 (89.2)

baseline

–

102 (87.9)

baseline

–

110 (100)

baseline

–

 Male

13 (10.4)

0.92 (0.25,3.44)

0.90

14 (10.9)

0.90 (0.28,2.90)

0.85

14 (12.1)

1.01 (0.31,3.34)

0.99

0

–

–

Mutation group

 No functional protein

43 (34.4)

baseline

–

43 (33.3)

baseline

–

40 (34.5)

baseline

–

34 (30.9)

baseline

–

 Missense/in-frame mutation within catalytic domain

38 (30.4)

1.27 (0.46,3.50)

0.64

40 (31.0)

1.62 (0.65,4.03)

0.30

34 (29.3)

1.73 (0.66,4.51)

0.27

34 (30.9)

12.14 (2.08,70.68)

0.01

 Truncation between aa172 and aa781

30 (24.0)

0.67 (0.24,1.89)

0.45

31 (24.0)

2.17 (0.80,5.91)

0.13

29 (25.0)

1.01 (0.36,2.82)

0.98

29 (26.4)

8.03 (1.35,48.00)

0.02

 Truncation after aa781

14 (11.2)

0.81 (0.21,3.07)

0.76

15 (11.6)

0.74 (0.21,2.58)

0.64

13 (11.2)

0.49 (0.11,2.13)

0.34

13 (11.8)

14.21 (1.83,110.22)

0.01