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Table 3 Multivariate logistic regression analysis of current gastrointestinal problems by age, gender and mutation group (n = 164)

From: Prevalence and onset of comorbidities in the CDKL5 disorder differ from Rett syndrome

  Any GI problem Constipation Reflux Air swallowing
  (n = 94) (n = 73) (n = 51) (n = 25)
  n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value n (%) OR (95 % CI) p value
  N = 125    N = 129    N = 116    N = 110   
Age group             
 0 to <5 years 50 (40.0) baseline 52 (40.3) baseline 48 (41.4) baseline 44 (40.0) baseline
 5 to < 10 years 42 (33.6) 2.03 (0.83,4.94) 0.12 42 (32.6) 2.12 (0.90,5.00) 0.08 36 (31.0) 1.07 (0.42,2.72) 0.88 37 (33.6) 1.35 (0.37,4.86) 0.65
 10 years or older 33 (26.4) 3.5 (1.22,10.08) 0.02 35 (27.1) 2.78 (1.14,6.74) 0.02 32 (27.6) 2.24 (0.88,5.71) 0.09 29 (26.4) 7.48 (1.96,28.53) 0.003
Gender             
 Female 112 (89.6) baseline 115 (89.2) baseline 102 (87.9) baseline 110 (100) baseline
 Male 13 (10.4) 0.92 (0.25,3.44) 0.90 14 (10.9) 0.90 (0.28,2.90) 0.85 14 (12.1) 1.01 (0.31,3.34) 0.99 0
Mutation group             
 No functional protein 43 (34.4) baseline 43 (33.3) baseline 40 (34.5) baseline 34 (30.9) baseline
 Missense/in-frame mutation within catalytic domain 38 (30.4) 1.27 (0.46,3.50) 0.64 40 (31.0) 1.62 (0.65,4.03) 0.30 34 (29.3) 1.73 (0.66,4.51) 0.27 34 (30.9) 12.14 (2.08,70.68) 0.01
 Truncation between aa172 and aa781 30 (24.0) 0.67 (0.24,1.89) 0.45 31 (24.0) 2.17 (0.80,5.91) 0.13 29 (25.0) 1.01 (0.36,2.82) 0.98 29 (26.4) 8.03 (1.35,48.00) 0.02
 Truncation after aa781 14 (11.2) 0.81 (0.21,3.07) 0.76 15 (11.6) 0.74 (0.21,2.58) 0.64 13 (11.2) 0.49 (0.11,2.13) 0.34 13 (11.8) 14.21 (1.83,110.22) 0.01
  1. OR odds ratio - the relative odds of having the outcome in the category of interest compared to the odds of having the outcome in the baseline category; CI confidence interval