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Table 2 Median percent decrease (range) of biochemical markers in treatment naïve patients

From: Biochemical response to substrate reduction therapy versus enzyme replacement therapy in Gaucher disease type 1 patients

   Eliglustat ERT Miglustat
n = 4 n = 4 n = 2
Year Median (range) Median (range) Median (range)
Chitotriosidase 1 68.3 (40–80.9) 79.6 (61.9–91.1) 41.8 (41.4–42.2)
2 88.8 (77–97.7) 88.1 (77.9–91.9) 37.3 (28.9–45.6)
CCL18 1 45.4 (35.3–52.9) 43.1 (21.5–65) -9.6 (-22.1–2.9)
2 72.9 (62.7–78.3) 53.7 (43.4–85.7) 10.3 (2.8–17.7)
GlcSph 1 75.9 (62.4–78.3) 71.9 (20.6–81.3) 25.8 (23.8–27.7)
2 86.2 (78.4–92.9) 78.4 (64.7–90.6) 47.8 (45.4–50.2)
GlcCer 1 79.8 (76.4–89.4) 35.1 (-6.9–56.8) 37.6 (37.5–37.6)
2 84.1 (74.3–90.6) 36.4 (19–67.1) 39.5 (25.3–53.6)