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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Biochemical response to substrate reduction therapy versus enzyme replacement therapy in Gaucher disease type 1 patients

Fig. 3

Clinical response of different treatment modalities in naïve patients (graphs ACEGI) and switching from ERT to SRT (graphs BDFHJ). Follow up of patients 15 and 16 is incomplete due to early treatment discontinuation. a, b Liver volume. c, d Spleen volume. e, f Platelet count, splenectomized patients are depicted in dotted lines. g, h Hemoglobin levels, splenectomized patients are depicted in dotted lines. i, j Average bone marrow fat fraction of corpora L3, L4, L5 (data are missing of patient 12. Due to multiple bone complications fat fraction assessments are not reliable, patient 16 and 17 because of early treatment discontinuation). Below the indicated threshold value of 0.23 (black dotted-line), the risk for bone complications is increased. * blue star indicates patient 19

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172