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Table 2 Risk of bias assessment of the RCTs on CJD [38, 39, 41] and on paediatric MS [28] (+ low risk of bias, ? unclear risk of bias, - high risk of bias)

From: Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions

Reference Random sequence generation (selection bias) Allocation concealment (selection bias) Blinding of participants and personnel (performance bias) Blinding of outcome assessment (detection bias) Incomplete outcome data (attrition bias) Selective reporting (reporting bias)
[41] + + + + + +
[39] + + + + + +
[38] + + + + + +
[28] + ? - ? + +