Skip to main content

Table 3 The median values of the haematological parameters of the 39 C1-INH-HAE patients taking danazol before treatment as well as after 1-, 3-, and 5-year treatment with danazol

From: The effect of long-term danazol treatment on haematological parameters in hereditary angioedema

Parameter Gender Reference range Median before 1-year treatment Median after 1-year treatment Median before 3-year treatment Median after 3-year treatment Median before 5-year treatment Median after 5-year treatment
WBC Males 4.0–10.0 × 109/L 8.54 (5.83–10.5) 6.76 (5.70–9.06) 7.90 (5.83–10.0) 6.57 (5.40–8.63) 8.30 (5.83–10.10) 7.83 (5.52–8.53)
Females 7.60 (6.70–10.57) 7.80 (6.55–9.22) 7.60 (7.03–9.88) 7.88 (6.48–8.61) 7.60 (6.80–10.7) 6.45 (5.43–7.12)*
RBC Males 4.50–5.90 × 1012/L 5.17 (4.82–5.37) 5.14 (4.79–5.35) 5.21 (4.84–5.38) 5.14 (4.70–5.29) 5.20 (4.82–5.39) 5.21 (4.74–5.52)
Females 4.10–5.10 × 1012/L 4.60 (4.33–4.73) 4.61 (4.31–4.81) 4.60 (4.33–4.73) 4.55 (4.45–4.69) 4.62 (4.27–4.76) 4.60 (4.32–4.67)
Hb Males 140–175 g/L 154 (149–161) 153 (146–160) 154 (152–161) 154 (144–158) 156 (151–161) 157 (151–162)
Females 123–153 g/L 133 (124–142) 137 (127–140) 133 (122–141) 135 (131–139) 133 (124–142) 138 (129–144)
Hct Males 0.36–0.48 L/L 0.46 (0.43–0.48) 0.45 (0.42–0.46) 0.46 (0.43–0.48) 0.45 (0.43–0.46) 0.45 (0.43–0.48) 0.45 (0.44–0.48)
Females 0.35–0.45 L/L 0.39 (0.38–0.42) 0.42 (0.38–0.42) 0.39 (0.38–0.42) 0.40 (0.39–0.41) 0.39 (0.38–0.42) 0.41 (0.38–0.43)
PLT Males 150–400 × 109/L 270 (232–300) 254 (230–315) 270 (231–314) 258 (227–333) 263 (230–322) 241 (222–285)
Females 291 (246–329) 265 (248–323) 302 (250–346) 286 (253–313) 302 (257–336) 262 (218–297)*
  1. The median values of the haematological parameters of the 39 C1-INH-HAE patients (18 males and 21 females) taking danazol (with 25th and 75th percentiles in parentheses) before treatment as well as 1-, 3-, and 5-year treatment with danazol, as analyzed by a paired (Wilcoxon’s) t-test. A significance of p < 0.05 is indicated by an asterisk (*)
\