Fig. 3

Individual patient ISIs across time, indicated in months since treatment onset. In this and the following two figures, plots with red triangles are treated patients, blue triangles are reported in months since first visit of the untreated patient (UT5) and the two patients recorded before miglustat intervention (UT1 and UT2). The grey lines are the treated and untreated model fits, with intercept varying across participant). The black lines are individually fit regression models with blue shaded ± SE (allowing comparison of individual performance to the overall LME model fit across all participants in that group). Patient numbering is as in Figs. 1 and 2