Fig. 3

Publication date, origin and topics of the identified GLs and RCs. a Number of GLs and RCs published between 2000 and 2015. b Correlation between year of publication from 2000 to 2014 and number of GLs or RCs, linear regression. c Country of origin of the GLs and RCs. For each document, the countries of origin of all the authors were analyzed and GLs and RCs were classified as: from Europe, from USA or from miscellaneous origin (different continents or different American countries). Data are expressed as relative percentage referred to total GLs and RCs covering the same group of disorders. d Topics covered by the identified GLs and RCs. A: amino acid and organic acid metabolism (n = 8); C: carbohydrate metabolism (n = 9); E: vitamin and non protein cofactor metabolism and transport (n = 2); F: porphyrin and hem metabolism (n = 1); G: mineral absorption and transport (n = 5); H: energy metabolism (n = 3); I: lysosomal and lysosomal-related organelles (n = 27)