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Table 2 Comparison between the average SCQ scores for each clinical and genetic feature

From: Autism spectrum disorder in tuberous sclerosis complex: searching for risk markers

Gender

Male

Female

 

 Number of patients

18 (42.8 %)

24 (57.1 %)

NS

 Average SCQ score ±SD

10.6 ± 7.0

11.2 ± 8.5

Mutation

TSC1

TSC2

NMI

 

 Number of patients

10 (23.8 %)

30 (71.4 %)

2 (4.8 %)

 

 Average SCQ score ±SD

6.3 ± 6.0

12.6 ± 8.0

9.5 ± 3.5

NS p<0.03*

6.3 ± 6.0

12.6 ± 8.0

Epilepsy

Present

Absent

 

 Number of patients

36 (85.7 %)

6 (14.3 %)

 

 Average SCQ score ±SD

12.1 ±7.7

4.2 ± 4.7

p<0.05*

Onset of seizures

Before age 12 months

After age 12 months

 

 Number of patients

25 (69.4 %)

11 (30.6 %)

 

 Average SCQ score ±SD

14.0 ± 7.4

7.5 ± 6.4

p<0.05*

Spasms

Present

Absent

 

 Number of patients

18 (50 %)

18 (50 %)

 

 Average SCQ score ±SD

15.1 ±7.4

8.2 ± 6.6

p<0.05*

AEDs (at time of evaluation)

Monotherapy

Polytherapy

 

 Number of patients

13 (39.4 %)

20 (60.6 %)

 

 Average SCQ score ±SD

10.1 ± 9.0

13.6 ± 6.3

NS

Seizure frequency

None

Monthly

Weekly

 

 Number of patients

19 (52.8 %)

7 (19.4 %)

10 (27.8 %)

 

 Average SCQ score ±SD

9.9 ± 8.0

15.7 ± 5.3

13.6 ± 7.8

NS

IQ

IQ≥70

IQ<70

 

 Number of patients

11 (36.7 %)

19 (63.3 %)

 

 Average SCQ score ±SD

4.8 ± 4.3

11.5 ±6.7

p<0.05*

Sleep disorders

Present

Absent

 

 Number of patients

9 (21.4 %)

33 (78.6 %)

 

 Average SCQ score ±SD

16.4 ± 8.0

9.4 ± 7.1

p<0.05*

Psychiatric disorders

Present

Absent

 

 Number of patients

17 (41.5 %)

24 (58.5 %)

 

 Average SCQ score ±SD

13.3 ± 8.7

8.6 ± 6.0

p<0.05*

  1. Statistically significant findings are written in bold
  2. NS not statistically significant; AEDs antiepileptic drugs