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Table 2 Comparison between the average SCQ scores for each clinical and genetic feature

From: Autism spectrum disorder in tuberous sclerosis complex: searching for risk markers

Gender Male Female  
 Number of patients 18 (42.8 %) 24 (57.1 %) NS
 Average SCQ score ±SD 10.6 ± 7.0 11.2 ± 8.5
Mutation TSC1 TSC2 NMI  
 Number of patients 10 (23.8 %) 30 (71.4 %) 2 (4.8 %)  
 Average SCQ score ±SD 6.3 ± 6.0 12.6 ± 8.0 9.5 ± 3.5 NS p<0.03*
6.3 ± 6.0 12.6 ± 8.0
Epilepsy Present Absent  
 Number of patients 36 (85.7 %) 6 (14.3 %)  
 Average SCQ score ±SD 12.1 ±7.7 4.2 ± 4.7 p<0.05*
Onset of seizures Before age 12 months After age 12 months  
 Number of patients 25 (69.4 %) 11 (30.6 %)  
 Average SCQ score ±SD 14.0 ± 7.4 7.5 ± 6.4 p<0.05*
Spasms Present Absent  
 Number of patients 18 (50 %) 18 (50 %)  
 Average SCQ score ±SD 15.1 ±7.4 8.2 ± 6.6 p<0.05*
AEDs (at time of evaluation) Monotherapy Polytherapy  
 Number of patients 13 (39.4 %) 20 (60.6 %)  
 Average SCQ score ±SD 10.1 ± 9.0 13.6 ± 6.3 NS
Seizure frequency None Monthly Weekly  
 Number of patients 19 (52.8 %) 7 (19.4 %) 10 (27.8 %)  
 Average SCQ score ±SD 9.9 ± 8.0 15.7 ± 5.3 13.6 ± 7.8 NS
IQ IQ≥70 IQ<70  
 Number of patients 11 (36.7 %) 19 (63.3 %)  
 Average SCQ score ±SD 4.8 ± 4.3 11.5 ±6.7 p<0.05*
Sleep disorders Present Absent  
 Number of patients 9 (21.4 %) 33 (78.6 %)  
 Average SCQ score ±SD 16.4 ± 8.0 9.4 ± 7.1 p<0.05*
Psychiatric disorders Present Absent  
 Number of patients 17 (41.5 %) 24 (58.5 %)  
 Average SCQ score ±SD 13.3 ± 8.7 8.6 ± 6.0 p<0.05*
  1. Statistically significant findings are written in bold
  2. NS not statistically significant; AEDs antiepileptic drugs
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