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Table 4 Supportive therapeutic options in ZSDs

From: Zellweger spectrum disorders: clinical overview and management approach

Symptom/disease Treatment/intervention
Adrenal insufficiency Cortisone
Coagulopathy Vitamin K suppletion
Enamel hypoplasia Dentist referral
Epilepsy Standard antiepileptic drugs
Hearing impairment Hearing aids, cochlear implant
High phytanic acid plasma level Phytanic acid restricted diet
Hyperoxaluria Oral citrate treatment Sufficient fluid intake
Insufficient calory intake Gastrostomy
Low levels of fat-soluble vitamins (A, D, E) Vitamin suppletion
Visual impairment Cataract removal, glasses and ophthalmologist referral