Table 4 Supportive therapeutic options in ZSDs
From: Zellweger spectrum disorders: clinical overview and management approach
Symptom/disease | Treatment/intervention |
|---|---|
Adrenal insufficiency | Cortisone |
Coagulopathy | Vitamin K suppletion |
Enamel hypoplasia | Dentist referral |
Epilepsy | Standard antiepileptic drugs |
Hearing impairment | Hearing aids, cochlear implant |
High phytanic acid plasma level | Phytanic acid restricted diet |
Hyperoxaluria | Oral citrate treatment Sufficient fluid intake |
Insufficient calory intake | Gastrostomy |
Low levels of fat-soluble vitamins (A, D, E) | Vitamin suppletion |
Visual impairment | Cataract removal, glasses and ophthalmologist referral |