Fig. 3From: Zellweger spectrum disorders: clinical overview and management approachDiagnostic flow-chart for ZSDs. a Very long chain fatty acids: C26:0, C24:0/C22:0 ratio, C26:0/C22:0 ratio. b Single enzyme deficiency with phenotypical ZSD similarities like ACOX1 deficiency and DBP deficiency. c Next generation sequencing (NGS) of all PEX genes is advised when complementation analysis is not practicableBack to article page