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Table 4 Bronchodilator response in patients vs. controls

From: Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency

Bronchodilator responsea

   
 

Mean % change (SD)

 

P value (T-test)

Spirometry

Patients n = 4

Controls n = 82

 

 ΔFEV1

3.3 (4.7)

5.5 (9.7)

0.607

 ΔFVC

1.3 (6.5)

2.7 (7.0)

0.341

 ΔFEV1 / FVC

2.5 (4.6)

4.3 (8.1)

0.672

 ΔPEF

−4.5 (13.7)

6.5 (15.5)

0.164

Impulse oscillometry

Patients n = 10

Controls n = 82

 

 ΔR5

−15.3 (15.9)

−14.6 (12.0)

0.438

 ΔR10

−15.4 (12.5)

−14.5 (10.7)

0.809

 ΔR20

−12.6 (11.1)

−9.6 (12.7)

0.483

 ΔR5-R20

−8.5 (28.7)

−11.7 (29.8)

0.745

 ΔX5

−18.2 (31.9)

−14.7 (24.0)

0.673

 ΔAX

−21.6 (29.7)

−33.3(22.6)

0.139

 ΔFres

−13.4 (15.8)

−13.1 (20.9)

0.961

  1. aAirway reversibility was considered evident when there was an improvement in any of the following bronchodilator parameters : ΔR5 ≥ −20 %, ΔR10 ≥ −15 %, ΔR20 ≥ −20 %, ΔAX ≥ −45 %, and ΔFres ≥ −25 %. By design, the percent improvement (reversibility) is displayed as a negative number because it indicates a magnitude decrease in resistance or reactance