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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Late infantile metachromatic leukodystrophy: Clinical manifestations of five Taiwanese patients and Genetic features in Asia

Fig. 1

Cranial MRIs of our patients. a-c represents patient 1, d-f patient 2, g-i patient 3, j-l patient 4, and m-o patient 5. (a, d, g, j, m) Hypointense radially oriented stripes and dots seen within the hyperintense cerebral white matter (resembling tiger skin) on T2-weighted axial imaging. (b, e, h, k, n) Hypointense dots resembling leopard skin seen on T2-weighted axial imaging at the level of centrum ovale. (c, f, i, l, o) Iso to hyperintense dots seen in the cerebral white matter on T1-weighted imaging. This pattern of dysmyelination resembles the skin of tiger (radial stripes) and leopard (dots), the so-called tigroid and leopard pattern of dysmyelination in metachromatic leukodystrophy

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172