Initial report of the osteogenesis imperfecta adult natural history initiative

Table 2 Prevalence of self-reported conditions and symptoms by adults with OI shown by self-reported disease severity compared with prevalence reported by both genders in NHIS 2012 or, where specified, in other adult benchmark databases

Condition			Prevalence of reported conditions and symptoms (%)
	Mild OI	Moderate OI	Severe OI	All	NHIS 2012 [23]
	(n = 535)	(n = 329)	(n = 92)	(n = 959)	NHIS 2012 [23]
Astigmatism	33	37	30	34	3.6 [24]
Blood vessel problem (rupture, aneurysm)	5	6	10	6	1–12 [25]
Bruising	47	41	15	42	18 (12–55)
Cancer	11	9	4	10	5–8 [26]
Cataracts	8	9	11	8	8.6 [25]
Constipation	23	29	34	26	12–19 [27, 28]
Coronary artery disease	6	11	8	4, 7	5–17 (<65 yr)
Coronary artery disease	20	12	0	10, 10	30 (>65 yr) [25]
Heart attack	6	9	7	7	2.9 (>20 yr) [25]
Cough	11	19	30	16	9–33 [29]
Diabetes mellitus	11	11	8	11	8–10 [23]
Dry skin	35	30	28	32	14–19 (<65 yr)
Dry skin	49	62	0	52	56 (>65 yr) [30]
Fractures	59	72	66	64	1–3 [31]
Fragile teeth	29	46	57	38	10–19 [32]
Glaucoma	8	7	2	7	2 [24]
Hearing loss	59	57	58	58	2–16 [23]
Heart valve problem	6	9	4	7	2–4 [25]
Heartburn	30	40	30	33	3–7 [33]
Hemorrhoids	17	18	11	17	4 [28]
High cholesterol	29	27	12	26	8–27 [23, 25]
Hypertension	32	42	34	35	21–36 [34]
Kidney/bladder stones	8	14	4	9	8.8 [35]
Near sightedness	50	49	39	49	33–40 [24]
Numbness	18	22	25	20	0.1–8 [36]
Obesity (BMI > 30 kg/m²)	29	42	50	35	28–35 [23]
Shortness of breath	20	31	47	26	10–18 (<65 yr)
Shortness of breath	28	31	60	31	30 + (>65 yr) [37]
Sleep apnea	9	17	32	14	<6 [38]
Stroke	3	6	8	4	3 [25]
Wheezing/asthma	12	14	27	14	8–13 [37]

ISSN: 1750-1172