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Table 2 Prevalence of self-reported conditions and symptoms by adults with OI shown by self-reported disease severity compared with prevalence reported by both genders in NHIS 2012 or, where specified, in other adult benchmark databases

From: Initial report of the osteogenesis imperfecta adult natural history initiative

Condition   Prevalence of reported conditions and symptoms (%)
Mild OI Moderate OI Severe OI All NHIS 2012 [23]
(n = 535) (n = 329) (n = 92) (n = 959)
Astigmatism 33 37 30 34 3.6 [24]
Blood vessel problem (rupture, aneurysm) 5 6 10 6 1–12 [25]
Bruising 47 41 15 42 18 (12–55)
Cancer 11 9 4 10 5–8 [26]
Cataracts 8 9 11 8 8.6 [25]
Constipation 23 29 34 26 12–19 [27, 28]
Coronary artery disease 6 11 8 4, 7 5–17 (<65 yr)
20 12 0 10, 10 30 (>65 yr) [25]
Heart attack 6 9 7 7 2.9 (>20 yr) [25]
Cough 11 19 30 16 9–33 [29]
Diabetes mellitus 11 11 8 11 8–10 [23]
Dry skin 35 30 28 32 14–19 (<65 yr)
49 62 0 52 56 (>65 yr) [30]
Fractures 59 72 66 64 1–3 [31]
Fragile teeth 29 46 57 38 10–19 [32]
Glaucoma 8 7 2 7 2 [24]
Hearing loss 59 57 58 58 2–16 [23]
Heart valve problem 6 9 4 7 2–4 [25]
Heartburn 30 40 30 33 3–7 [33]
Hemorrhoids 17 18 11 17 4 [28]
High cholesterol 29 27 12 26 8–27 [23, 25]
Hypertension 32 42 34 35 21–36 [34]
Kidney/bladder stones 8 14 4 9 8.8 [35]
Near sightedness 50 49 39 49 33–40 [24]
Numbness 18 22 25 20 0.1–8 [36]
Obesity (BMI > 30 kg/m2) 29 42 50 35 28–35 [23]
Shortness of breath 20 31 47 26 10–18 (<65 yr)
28 31 60 31 30 + (>65 yr) [37]
Sleep apnea 9 17 32 14 <6 [38]
Stroke 3 6 8 4 3 [25]
Wheezing/asthma 12 14 27 14 8–13 [37]
  1. NHIS 2012: “Any hearing trouble without use of hearing aid or listening device”