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Table 3 Neurodegenerative markers in cerebellum following enzyme replacement therapy

From: The effects of intracisternal enzyme replacement versus sham treatment on central neuropathology in preclinical canine fucosidosis

Neurodegenerative markers in cerebellum

CVT (n = 3)

AET (n = 3)

AVT (n = 2–3)

CI

Vacuolation in molecular layer

0.26 ± 0.0 a

5.47 ± 1.1 b

5.52 ± 1.2 b

0.09

Vacuolation in cerebellar nuclei

0.52 ± 0.2 a

3.38 ± 1.6 b

4.87 ± 2.3 b

0.30

Purkinje cell counts

12 ± 0.8 a

10 ± 0.5 b

10 ± 0.2 b

0.00

Myelination

67.18 ± 0.8 a

58.00 ± 3.2 b

55.02 ± 2.3 b

0.05

Astrocytosis

6.77 ± 0.4 a

13.05 ± 0.8 b

14.24 ± 0.9 b

0.08

Axonal spheroids

0.01 ± 0.5 a

0.84 ± 0.6 b

0.84 ± 0.0* b

0.00

  1. Mean ± SEM. a,b different letters indicate significant difference between affected dogs and unaffected controls at p < 0.05