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Table 2 The effect of intracisternal ERT on measures of oligodendrocyte loss and apoptosis

From: The effects of intracisternal enzyme replacement versus sham treatment on central neuropathology in preclinical canine fucosidosis

Measure

CVT (n = 3)

AET (n = 3)

AVT(n = 3)

CI

Oligodendrocytes per mm2 white matter

Cerebellar white matter

907 ± 66 a

584 ± 66 b

521 ± 66 b

−0.12

Corpus callosum

1366 ± 60 a

889 ± 60 b

603 ± 60 c

−0.47

Percentage of CASP6 staining

Cerebellar white matter

1.2 ± 0.5 %

1.3 ± 0.5 %

2.0 ± 0.8 %

0.35

Corpus callosum’

0.5 ± 0.2 % a

5.0 ± 1.9 % b

5.5 ± 2.2 % b

0.09

Purkinje cells

20.9 ± 7.2 % a

49.2 ± 7.2 % b

c 77.7 ± 7.2 % c

0.37

  1. Mean ± SEM. a,b,c different letters indicate significant difference at p < 0.05