Fig. 3

Quantification of neurodegenerative and inflammatory markers in CNS following intracisternal enzyme infusion. Quantification of (a) area of ubiquitin staining in frontal cerebral cortex, (b) pyramidal neurons in frontal cerebral cortex, (c) area vacuolation and, (d) area of GFAP staining in medulla, (e) area vacuolation in cervical spinal cord grey matter. Expression levels of (f) LAMP-1, (g) TGF-β, (h) IL-6 and (i) IL-8 genes in superficial frontal cerebral cortex. Different letters (^{a, b, c}) indicate significant difference between groups at p < 0.05