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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Effect of systemic high dose enzyme replacement therapy on the improvement of CNS defects in a mouse model of mucopolysaccharidosis type II

Fig. 2

Effects of ERT on the spontaneous alternation behavior Y-maze test in groups B and C. In (a) and (b), the left picture shows the percentage of spontaneous alternations, and the right picture shows the number of entries. In group B, the KO group significantly decreased their spontaneous alternation behavior compared with the WT group (a, p < 0.05). This behavior was recovered in the KO mice treated with 10 mg/kg, 5 mg/kg, or 5 mg/kg plus mannitol pretreatment (p < 0.05) without significantly changing the number of arm entries. The number of arm entries by KO mice was significantly decreased compared with that by the WT mice (p < 0.05). The two dose-change groups showed a trend towards improved spontaneous alternation behavior; however, these changes were not statistically significant. In group C, the KO group significantly decreased their spontaneous alternation behavior compared with the WT group (b, p < 0.05). No treated mice of group C showed any significant improvement of spontaneous alternation behavior

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