Fig. 1

The walking footprint patterns of all of the mice at the end of the experiment. The walking footprint patterns show the forepaws (red) and hindpaws (blue) of each mouse of groups A (a), B (b), and C (c). Most WT mice walked in a straight line away from the investigator. By contrast, the IDS KO mice had an impaired walking pattern; their gait was slow, and they tended to walk in an unstable manner, with a short-stepped gait of approximately half the stride length of WT mice. The KO mice treated with any dose of IDS showed a trend towards amelioration of these abnormalities in all groups