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Table 2 Parameters of the coagulation and of the fibrinolytic system in symptom-free periods and during attacks, in the same C1-INH-HAE patients. The Linear Mixed Model was used to simulate random effects and repeated measures, to detect differences between the attacks occurring at a “Single site” vs. at “Multiple sites”, or in subcutaneous (SC) vs. submucosal (SM) location

From: Comprehensive study into the activation of the plasma enzyme systems during attacks of hereditary angioedema due to C1-inhibitor deficiency

Dependent variable

Comparison made between:

Estimatea

95 % Confidence interval

P valuea

Lower bound

Upper bound

Prothrombin time, sec

Attack at single site vs. multiple sites

−0.478

−0.590

−0.367

0.018

Attack in SC or SM location

0.052

−0.004

0.109

0.816

D-dimer, mg/L

Attack at single site vs. multiple sites

3.504

2.699

4.308

0.002

Attack in SC or SM location

−1.737

−1.953

−1.522

0.060

Plasminogen, %

Attack at single site vs. multiple sites

−16.619

−21.280

−11.960

0.008

Attack in SC or SM location

10.778

8.763

12.792

0.051

  1. aFor the difference between the “during attack” and the “symptom-free” samples