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Table 2 Parameters of the coagulation and of the fibrinolytic system in symptom-free periods and during attacks, in the same C1-INH-HAE patients. The Linear Mixed Model was used to simulate random effects and repeated measures, to detect differences between the attacks occurring at a “Single site” vs. at “Multiple sites”, or in subcutaneous (SC) vs. submucosal (SM) location

From: Comprehensive study into the activation of the plasma enzyme systems during attacks of hereditary angioedema due to C1-inhibitor deficiency

Dependent variable Comparison made between: Estimatea 95 % Confidence interval P valuea
Lower bound Upper bound
Prothrombin time, sec Attack at single site vs. multiple sites −0.478 −0.590 −0.367 0.018
Attack in SC or SM location 0.052 −0.004 0.109 0.816
D-dimer, mg/L Attack at single site vs. multiple sites 3.504 2.699 4.308 0.002
Attack in SC or SM location −1.737 −1.953 −1.522 0.060
Plasminogen, % Attack at single site vs. multiple sites −16.619 −21.280 −11.960 0.008
Attack in SC or SM location 10.778 8.763 12.792 0.051
  1. aFor the difference between the “during attack” and the “symptom-free” samples