Skip to main content

Table 1 The median levels of the proteins and markers of plasma enzyme systems in symptom-free periods and during attacks in the same C1-INH-HAE patients. The Linear Mixed Model was used on all measured parameters to simulate random effects and repeated measures, as well as to detect differences between the “symptom-free” and the “during-attack” states of the same patients

From: Comprehensive study into the activation of the plasma enzyme systems during attacks of hereditary angioedema due to C1-inhibitor deficiency

Dependent variable

Estimatea

95 % Confidence interval

P-valuea

Lower limit

Upper limit

Factor XII, %

5.657

5.644

5.671

0.019

Factor XI, %

4.365

4.350

4.380

0.118

Prothrombin fragments 1 + 2, pmol/L

387.251

386.257

388.245

0.001

Prothrombin time, sec

−0.533

−0.534

−0.534

<0.0001

Activated partial thromboplastin time, sec

−3.039

−3.041

−3.037

<0.0001

Thrombin-anti-thrombin complex, μg/L

4.981

4.971

4.991

0.004

Fibrinogen, g/L

0.414

0.414

0.414

0.012

D-dimer, mg/L

3.105

3.104

3.106

<0.0001

Plasminogen, %

1.731

1.721

1.741

0.361

Plasminogen activator inhibitor-1, U/ml

−0.524

−0.525

−0.525

0.006

  1. aFor the difference between the “during attack” and the “symptom-free” samples