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Table 1 The median levels of the proteins and markers of plasma enzyme systems in symptom-free periods and during attacks in the same C1-INH-HAE patients. The Linear Mixed Model was used on all measured parameters to simulate random effects and repeated measures, as well as to detect differences between the “symptom-free” and the “during-attack” states of the same patients

From: Comprehensive study into the activation of the plasma enzyme systems during attacks of hereditary angioedema due to C1-inhibitor deficiency

Dependent variable Estimatea 95 % Confidence interval P-valuea
Lower limit Upper limit
Factor XII, % 5.657 5.644 5.671 0.019
Factor XI, % 4.365 4.350 4.380 0.118
Prothrombin fragments 1 + 2, pmol/L 387.251 386.257 388.245 0.001
Prothrombin time, sec −0.533 −0.534 −0.534 <0.0001
Activated partial thromboplastin time, sec −3.039 −3.041 −3.037 <0.0001
Thrombin-anti-thrombin complex, μg/L 4.981 4.971 4.991 0.004
Fibrinogen, g/L 0.414 0.414 0.414 0.012
D-dimer, mg/L 3.105 3.104 3.106 <0.0001
Plasminogen, % 1.731 1.721 1.741 0.361
Plasminogen activator inhibitor-1, U/ml −0.524 −0.525 −0.525 0.006
  1. aFor the difference between the “during attack” and the “symptom-free” samples