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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Clinical heterogeneity and potential high pathogenicity of the Mmalton Alpha 1 antitrypsin allele at the homozygous, compound heterozygous and heterozygous states

Fig. 2

Liver tissue was obtained by percutaneous liver biopsy of the proband. a Hematein Phloxin Safran (HPS) coloration showing collagen fibrosis around hepatocytes with numerous round eosinophilic cytoplasmic inclusions; (b) PAS staining with diastase digestion showing abundant hyaline globules containing A1AT accumulated within periportal hepatocytes; (c) Immunohistochemical staining using a monoclonal antibody to A1AT

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