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Table 1 Effect of genotype on VEP latency and amplitude in naive PN75 Npc1 +/+ and Npc1 −/− micea

From: Visual evoked potentials of Niemann-Pick type C1 mice reveal an impairment of the visual pathway that is rescued by 2-hydroxypropyl-ß-cyclodextrin

 

Npc1 +/+ (n = 12)

Npc1 −/− (n = 12)

t

(df) b

p c

Latency, N1

27.59 ± 0.16d

28.98 ± 0.59

2.29

(22)

0.0396

Latency, N2

35.08 ± 0.62

37.35 ± 0.55

2.75

(22)

0.0118

Latency, N3

43.37 ± 0.81

44.70 ± 0.85

1.14

(22)

0.2778

Amplitude, N1

105.20 ± 13.67

22.00 ± 6.32

5.52

(22)

0.0001

  1. aThe mice examined in this experiment did not receive any kind of experimental manipulation before electrode implants and VEP recording
  2. bDegree of freedom
  3. c p was evaluated by unpaired two-tailed Student’s t test
  4. dmean ± SEM
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172