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Fig. 6 | Orphanet Journal of Rare Diseases

Fig. 6

From: Visual evoked potentials of Niemann-Pick type C1 mice reveal an impairment of the visual pathway that is rescued by 2-hydroxypropyl-ß-cyclodextrin

Fig. 6

HPßCD rescues the reduced cell number of Npc1 −/− mice. Brain sections of PN75, either sham or HPßCD-treated, Npc1 +/+ and Npc1 −/− mice were stained with haematoxylin and eosin. Representative fields (see Additional file 3: Figure S3) of a primary visual cortex and b dorsal lateral geniculate nucleus (dLGN) are shown in the figure. c Histograms indicate cell densities (mean ± SEM) determined on 5 randomly selected 400 μm2 regions of primary visual cortex (V1) and lateral geniculate nucleus (dLGN). Asterisk indicates a significant difference (*, p < 0.05). fmj: forceps major corpus callosum; I-VI cortical layer. Scale bars indicate 50 μm (a, b)

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