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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Propranolol reduces viability and induces apoptosis in hemangioblastoma cells from von Hippel-Lindau patients

Fig. 2

Propranolol decreases the expression of HIF target genes in hemangioblastoma cells. a The transcription levels of HIF target genes, VEGF, EPO and SOX2, were compared with the endogenous control of 18S ribosomal RNA. Propranolol treatment led to a dose-dependent decrease in mRNA expression as a consequence of the reduced expression of HIF targets. Differences were statistically significant according to the Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.005. b VEGF soluble levels were measured by ELISA assay in supernatants of hemangioblastoma cultures treated with propranolol. Soluble VEGF levels were decreased in propranolol-treated cells compared with untreated ones

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