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Table 1 Summary of parameters and statistics for bone mineral analysis by DEXA and tibia length by X-ray in the IDUA KO mice at the age of 16 weeks (mean ± SEM)

From: Decreased performance in IDUA knockout mouse mimic limitations of joint function and locomotion in patients with Hurler syndrome

  Parameters Male Female
WT (n = 4) KO (n = 4) WT (n = 5) KO (n = 6)
Femur BMD (g/cm2) 0.064 ± 0.001 0.074 ± 0.002**** 0.059 ± 0.002 0.068 ± 0.002***
BMC (g) 0.031 ± 0.001 0.037 ± 0.0002* 0.03 ± 0.0008 0.038 ± 0.001****
Bone area (cm2) 0.48 ± 0.007 0.505 ± 0.006**** 0.502 ± 0.018 0.553 ± 0.006
Body BMD (g/cm2) 0.047 ± 0.001 0.053 ± 0.0005** 0.046 ± 0.0004 0.051 ± 0.0006*
BMC (g) 0.547 ± 0.032 0.755 ± 0.027** 0.0541 ± 0.014 0.700 ± 0.017*
Bone area (cm2) 11.703 ± 0.388 14.233 ± 0.503*** 11.806 ± 0.348 13.787 ± 0.237*
  Tibia length (mm) 18.043 ± 0.239 17.555 ± 0.147 18.396 ± 0.110 18.099 ± 0.105
  1. *p < 0.001, **p < 0.005, ***p < 0.01, ****p < 0.05
  2. BMD: Bone mineral density; BMC: Bone mineral content