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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Decreased performance in IDUA knockout mouse mimic limitations of joint function and locomotion in patients with Hurler syndrome

Fig. 3

Behavior analysis including grip strength, rotarod, and open-field tests in 9-week-old female IDUA KO mice (n = 5). a, b IDUA KO mice had reduced forelimb strength and reduced forelimb combined with hindlimb grip strength. The data were analyzed by normalizing the mean to body weight. Each mouse was tested three times. c Rotarod performance was analyzed daily for 3 days. Although no significant difference was observed, there was a decrease of latency to fall tendency in IDUA KO mice. d, e In the open-field test, IDUA KO mice traveled shorter distances and more slowly compared with wild-type mice. Zones 1 and 2 are located at peripheral area, and zone 3 represents central zone

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