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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Decreased performance in IDUA knockout mouse mimic limitations of joint function and locomotion in patients with Hurler syndrome

Fig. 2

Glycosaminoglycan (GAG) excretion in the urine and accumulation of GAGs in several organs in IDUA KO mice. a The urinary excretion of GAGs of 9-week-old (n = 4) and 19-week-old (n = 4) KO mice were significantly higher than those of wild-type mice at the same ages (n = 5). The data were presented as mean ± SEM. b GAGs accumulated in the tissues of IDUA KO mice were higher than those of wild-type mice. Asterisk (*) indicates a statistically significant difference (p < 0.05). c Histological analysis of kidney and liver tissues: By 10 weeks of age, GAGs storage within the reticulo-endothelial system had occurred and hepatocyte vacuoles were noted. Arrow shows vacuoles

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