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Fig. 4 | Orphanet Journal of Rare Diseases

Fig. 4

From: Ichthyosis with confetti: clinics, molecular genetics and management

Fig. 4

Histology and immunofluorescence findings in ichthyosis with confetti caused by KRT10 mutation. The epidermis appears acanthotic and hyperkeratotic with parakeratosis, a reduced granular layer and cytoplasmic vacuolization in suprabasal keratinocytes (a). Higher magnification of the inset depicted in panel (a) highlighting the perinuclear vacuolization in suprabasal keratinocytes (b). Immunofluorescence labelling for keratin 10 (K10) shows reduced cytoplasmic staining in epidermal suprabasal cell layers, dot-like labelling of numerous nuclei in suprabasal epidermis and bright perinuclear rings (c). Higher magnification of the inset depicted in panel c showing that nuclear labeling is mainly localised to nucleoli (d). Haematoxylin-eosin staining (a and b), original magnification × 200 (a). Nuclear DAPI counterstaining (c and d), original magnification × 200 (c)

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