Fig. 2
From: Ichthyosis with confetti: clinics, molecular genetics and management
Major and minor clinical features of ichthyosis with confetti. Mammillae hypoplasia (a, arrowheads), palmoplantar hyperkeratosis (b), hypertrichosis of acral dorsal areas (arrowheads) (c) and back (d), scaling and hyperkeratosis of the scalp (e), large lunulae (f), long nail plates and unguis inflexus (g), severe eyelid ectropion (h). Clinical pictures are taken from a female at the age of 1 year (b, e, f), 2.5 (c) and 2.7 years (a, d) and a male at the age of 5 (g) and 8 (h) years. Note the healthy skin confetti-like spots (a, d: black rings) which became evident after hyperkeratosis shedding due to retinoid therapy