Fig. 1

Clinical variables with their degrees of severity, concerning the three most frequent mutations. Degrees of severity and their gray scale code are presented on the bottom of each bar plot, whereas absolute number of patients on the right. Different degrees of severity are given in percentages and the 3 most frequent mutations are always presented with the p.Glu815Lys mutation on the bottom, the p.Asp801Asn mutation in the middle and the p.Gly947Arg on the top