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Table 5 Adverse effects in 99 patients

From: Rapamycin and its analogues (rapalogs) for Tuberous Sclerosis Complex-associated tumors: a systematic review on non-randomized studies using meta-analysis

Adverse effect

Percentage of patients

Oral ulcer

54.5

Hypertriglyceridemia

28.3

Upper Respiratory Tract Infection

26.3

Acne/Acneiform Dermatitis

19.2

Sinusitis

16.2

Proteinuria

16.2

Hypercholesterolemia

15.2

Tinea/Other Skin problem

14.1

Leucocytosis

14.1

Diarrhoea

12.1

Anemia

12.1

Otitis Media

10.1

Pyrexia

8.1

Cellulitis

8.1

Joint pain

8.1

Urinary Tract Infection

7.1

Headache

6.1

Lymphopenia

6.1

Increased Alkaline Phosphatase

5.1

Irregular menses

5.1

Nose bleeding

5.1

Gastroenteritis

4

Otitis Externa

4

Incerased ALT, SGPT

4

Gastric Infection

3

Cough

3

Increased Creatinine Kinase

3

Peripheral Oedema

3

Fatigue

3

Vomiting

2

Gingival Hypertrophy

1

Myalgia

1

Acute Pyelonehpritis

1

Dry skin

1

Depression

1

Weight gain

1

Hypothyroidism

1

Retinal tear

1