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Table 3 Outcome on Subependymal Giant Cell Astrocytoma (SEGA)

From: Rapamycin and its analogues (rapalogs) for Tuberous Sclerosis Complex-associated tumors: a systematic review on non-randomized studies using meta-analysis

Studies Volume (cc) Diameter (mm)
Baseline n After treatment n Mean diff (95 % CI) Baseline n After treatment n Mean diff (95 % CI)
Case Reports 2.9 ± 2.4 3 1.2 ± 0.9 3 −1.7 (−4.6, 1.2) 35 ± 3.7 2 23 ± 1.8 2 −12.00 (−17.70, −6.30)
Kruger 2010 2.45 ± 2.81 28 1.3 ± 1.48 27 −1.01 (−2.33, 0.03)      
Dabora 2011       16.7 ± 6.4 13 12.4 ± 6.9 11 −4.3 (−9.66, 1.06)
Overall Effect      −1.23 (−2.32, −0.13)      −7.91 (−11.82, −4.01)
     p = 0.03      p < 0.0001
Heterogeneity      Chi2 = 0.12; I2 = 0 %      Chi2 = 3.72; I2 = 73 %