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Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Long-term outcomes after allogeneic hematopoietic stem cell transplantation for metachromatic leukodystrophy: the largest single-institution cohort report

Fig. 5

Brain MRI and NCV trends over time. All available clinical reports of brain MRI and peripheral nerve conduction velocity studies for the cohort were reviewed. Each MRI time-point was evaluated for change in white matter disease from the previous study as classified by the interpreting neuroradiologist. Each NCV time-point was evaluated for change in function from the previous study as classified by the interpreting neurologist. Each line represents a unique patient, while each circle represents an assessment. The dashed vertical line at time 0 reflects the time of transplant. Negative time points denote pre-HSCT studies. Red, yellow and green circles and preceding line segments indicate MRI or NCV studies that were worse than, the same as, or better than the previous assessment, respectively. Of evaluable patients at pre-transplant baseline, 97 % had an abnormal MRI while 92 % demonstrated peripheral neuropathy

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