Fig. 6

Naproxcinod significantly reduces cardiac fibrosis. Quantification of the cardiac fibrosis assessed by Picro-Sirius staining in mdx mice treated with vehicle (black bar), 30 mg/kg naproxcinod (white bar), or 20 mg/kg naproxen (grey bar) following 6 months of treatment. a Representative images of the heart and b quantification of the area of fibrosis in the heart, expressed as a percentage of the whole heart. Data are presented as mean ± SEM. *represents the comparison between vehicle and the treatment groups. #represents the comparison versus the naproxen-treated group. One-way ANOVA followed by Tukey post-hoc test. **P < 0.01; # P < 0.05. N = 5-10 mice/group. Bar = 1 mm