Fig. 4

Naproxcinod significantly reduces inflammation in diaphragm of mdx mice. Quantification of inflammation in the diaphragm of mdx mice treated with vehicle (black bar), 30 mg/kg naproxcinod (white bar) or 20 mg/kg naproxen (grey bar) following 6 months of treatment. a Representative histological images of the diaphragm muscle after H&E staining and b quantification of the area of inflammatory infiltrates, expressed as a percentage of muscle cross section. Data are presented as mean ± SEM. *represents the comparison between vehicle and treatment groups. One-way ANOVA followed by Tukey post hoc test. ***P < 0.001. N = 4-5 mice/group. Bar = 100 μm