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Table 1 Clinical and demographic data of patients

From: Excellent long-term outcome of renal transplantation in cystinosis patients

  cystinosis (n = 31) control (n = 93)  
Male / Female 16/15 59 / 34  
Age at ESRD (years) 18.8 (7.7-35.0) 19.8 (4.0-32.0) p = 0.07
Age at transplantation (years) 20.4 (7.1-36.5) 21.8 (13.6-32.0) * p = 0.03
Patient <19 yearsold (n=) 15 (48.4 %) 12 (12.9 %) * P < 0.001
Time from dialysis to transplantation (years) 1.3 (0.12-8.0) 1.6 (0.1-19.0) p = 0.1
Preemptive transplantation (n=) 9 (29.0 %) 12 (13.0 %) p = 0.06
Transplantation rank 1 (n = 25); 2 (n = 6) 1 (n = 75); 2 (n = 17)
BMI (kg/m2) 19.0 (14.3-28.7) 19.9 (14.0-25.0) p = 0.4
Diabetesmellitus (n=) 3 (9.7 %) 2 (2 %) p = 0.1
Initial graft data  
Living kidney donation (n=) 9 (29.0 %) 26 (28.6 %) p = 1
Deceased donor age (years) 30.0 (0.6-64.0) 37.0 (10.0-62.0) * p < 0.05
Extended criteria donor (n=) 1 (3.2 %) 3 (3.2 %) p = 1
Delayed graft function (n=) 4 (13.0 %) 18 (19.0 %) p = 0.6
Cold ischemia (hours) 17.5 (0.6-43.0) 17.5 (0.5-47.0) p = 0.4
Donor specific antibody presence (n=) 4 (13.0 %) 13 (14.0 %) p = 1
Induction treatment  
Steroids (n=) 30 (97.0 %) 93 (100 %) p = 0.3
Mycophenolate mofetil (n=) 18 (58.0 %) 53 (57.0 %) p = 1
Azathrioprine (n=) 13 (42.0 %) 15 (16.0 %)* p 0.006
Ciclosporine A (n=) 14 (45.0 %) 53 (57.0 %) p = 0.3
Tacrolimus (n=) 17 (55.0 %) 35 (37.6 %) p = 0.1
OKT3 (n=) 0 5 (5.4 %) p = 0.30
Thymoglobulin (n=) 18 (58.0 %) 53 (57.0 %) p = 1
Basiliximab (n=) 13 (42.0 %) 35 (37.6 %) p = 0.7
Follow up  
Duration of follow up (months) 144.1 (5.9-340.6) 72.0 (0.1-240.0) * p < 0.0001
Age at last follow up (months) 32.7 (18.7-54.5) 29.7 (18.7-43.3) * p = 0.01
ESRD at last follow up (n=) 6 (19.4 %) 29 (31.0 %) p = 0.3
eGFR (MDRD) at 180 months (mL/min/1.73 m2) 53.7 (19.0-103.0) 47.4 (7.7-111.4) p = 0.18
Maintenance treatment  
Stop of steroid during first year (n=) 3 (9.7 %) 15 (16.0 %) p = 0.6
Mycophenolate mofetil (n=) 15 (48.3 %) 43 (46.2 %) p = 0.84
Azathrioprine (n=) 8 (25.8 %) 25 (26.8 %) p = 1
Ciclosporine A (n=) 15 (48.0 %) 41 (44.0 %) p = 0.7
Tacrolimus (n=) 14 (45.0 %) 33 (35.0 %) p = 0.4
Everolimus (n=) 1 (3.0 %) 2 (2.0 %) p = 1
Graft complication  
Graft rejection (n=) 8 (26.0 %) 30 (32.0 %) p = 0.7
Infections (n=) 14 (45.0 %) 56 (60.0 %) p = 0.2
PTDM (n=) 4 (13.0 %) 5 (5.0 %) p = 0.2
Stroke (n=) 1 (3.0 %) 0 p = 0.3
Myocardial infarction (n=) 0 1 (1.0 %) p = 1
Death (n=) 1 (3.0 %) 2 (2.0 %) p = 1
  1. Continuous variables are shown as median ± SD.N, number; ESRD, end stage renal disease; BMI, body mass index; eGFR, estimated glomerular filtration rate; PTDM, post transplantation diabetes mellitus