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Table 2 Aerobic fitness measured in an incremental cycle test and a 6-min walk test before and after 12 weeks of training

From: Safety and efficacy of exercise training in adults with Pompe disease: evalution of endurance, muscle strength and core stability before and after a 12 week training program

 

Before training

After training

P-value**

 

Mean ± SD

Mean ± SD

 

Incremental cycle test (N = 22a)

   

Ventilatory threshold (VT)

   

 • Absolute values (l/min)

1.25 ± 0.36

1.38 ± 0.36

<0.01

 • Adjusted for body weight (ml/min/kg)

16.7 ± 4.3

18.5 ± 4.7

<0.01

 • VT/VO2 peak (%)

77.6 ± 12.1

78.3 ± 12.3

0.742

Data at exhaustion

   

 • Maximum workload (Wmax, Watt)

110 ± 52

122 ± 53

<0.01

 • Maximum heart rate (bpm)

156 ± 25

161 ± 20

0.16

 • Pulmonary ventilation (l/min)

59.6 ± 20.2

68.2 ± 21.0

<0.01

 • Tidal volume (l)

1.85 ± 0.48

1.85 ± 0.44

0.91

 • Gas exchange ratio

1.15 ± 0.09

1.14 ± 0.08

0.71

Peak oxygen uptake (VO2 peak)

   

 • Absolute values(l/min)

1.67 ± 0.62

1.82 ± 0.60

<0.01

 • Adjusted for body weight (ml/min/kg)

22.1 ± 7.0

24.1 ± 7.1

<0.01

 • As % of normal

69.4 ± 17.4

75.9 ± 18.0

<0.01

6-min walk test (N = 22)

   

 • Maximum walking distance (6MWT, m)

492 ± 89

508 ± 97

0.01

Pulmonary function test (N = 23)

   

 • Forced vital capacity (FVC, % of normal)

89.2 ± 12.6

90.0 ± 14.0

0.51

  1. ** For the difference before and after training (paired samples t-test)
  2. aOne patient was excluded because he did not reach the required maximum intensity