Glycogen storage disease type Ia (GSDIa) but not Glycogen storage disease type Ib (GSDIb) is associated to an increased risk of metabolic syndrome: possible role of microsomal glucose 6-phosphate accumulation

Table 1 Biochemical parameters of metabolic control in GSDI patients and controls at study entry

	GSDIa		Controls		GSDIb		Controls		Significance (p)
	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Ia vs C	Ib vs C	Ia vs Ib
Glucose (mg/dL)	92.80	17.79	85.70	5.92	106.71	27.43	91.57	10.58	0.11	0.08	0.22
Cholesterol (mg/dL)	191.40	35.30	149.00	23.00	104.60	15.02	139.00	32.30	0.001	0.02	0.001
Triglycerides (mg/dL)	379.10	176.10	88.20	35.30	116.40	74.69	108.00	38.30	0.001	0.73	0.001
Lactic acid (mg/dL)	2.16	0.47	1.33	0.22	3.26	1.78	1.35	0.22	0.001	0.001	0.08
Uric acid (mg/dL)	5.10	0.94	3.82	1.25	6.17	1.49	3.79	0.88	0.01	0.001	0.09
Bicarbonate (mEq/L)	22.40	2.24	26.31	1.91	24.60	13.00	24.57	1.79	0.001	0.98	0.60
Insulin (μU/L)	29.70	21.60	8.47	3.69	14.69	13.11	8.46	2.03	0.001	0.09	0.12

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