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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Acquired familial Mediterranean fever associated with a somatic MEFV mutation in a patient with JAK2 associated post-polycythemia myelofibrosis

Fig. 2

Detection, expansion and somatic distribution of the MEFV c.1955G>A mutation demonstrated by Sanger sequencing. a PBC DNA sample of the patient from 2009 b an earlier sample from 2005 c CD3-positive T cells, d PMC enriched fraction, e buccal cells, f kidney tubule cells. g Fnu4h1 RFLP of MEFV exon 10 visualized on a 4 % agarose E-gel. The MEFV mutation abolishes the second of three restriction sites yielding a longer, 350 base pairs fragment. h Small power photomicrograph demonstrating a glomerulus and tubular cells. h-a High power photomicrograph demonstrating a desiccated tubule cell, h-b before and h-c after laser capture microdissection procedure (hematoxylin and eosin stain magnification ×400)

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