Table 4 Correlations between the three genotype/subcellular localisation subgroups and biochemical and clinical test results
Analysis/clinical test | N | Subgr. 1, mean | Subgr. 2, mean | Subgr. 3, mean | Min. | Max. | Total, mean | SD | p-value Pairwise comparison* |
|---|---|---|---|---|---|---|---|---|---|
CSF-oligo (μmol/L) | 35/35 | 11.5 ± 2.3 | 11.9 ± 3.2 | 7.1 ± 2.0 | 4.0 | 19 | 10.7 | 3.4 | H0 3 = 2: p = 0.001, H0 3 = 1: p = 0.011 |
H0 2 = 1: p = 1.000 | |||||||||
Cognitive test (VR battery) (years) | 35/35 | 5.8 ± 1.7 | 5.3 ± 1.5 | 7.0 ± 0.9 | 3.0 | 9.0 | 5.8 | 1.6 | H0 3 = 2: p = 0.049, H0 3 = 1: p = 0.344, |
H0 2 = 1: p = 1.000 | |||||||||
Cognitive test (Memory Screening) (y) | 26/26 | 6.9 ± 1.9 | 5.4 ± 2.0 | 8.8 ± 1.2 | 2.3 | 10.2 | 6.5 | 2.3 | H0 3 = 2: p = 0.02, H0 3 = 1: p = 0.215, |
H0 2 = 1: p = 0.836 | |||||||||
FVC% (%) | 54/66* | 62.3 ± 20.7 | 77.5 ± 19 % | 90.7 ± 22.7 | 30 | 140 | 75.2 | 22.7 | H0 3 = 2: p = 0.296, H0 3 = 1: p = 0.003, |
H0 2 = 1: p = 0.042 | |||||||||
BOT-2 (Coor.) (points) | 35/35 | 16.3 ± 10.1 | 11.3 ± 10.8 | 22.5 ± 7.6 | 1 | 33 | 15 | 10.8 | H0 3 = 2:p = 0.047, H0 3 = 1: p = 0.713 |
H0 2 = 1: p = 0.773 | |||||||||
BOT-2 (Balance) (points) | 35/35 | 7.6 ± 6.2 | 8.4 ± 6.1 | 14.8 ± 7.9 | 1 | 26 | 9.7 | 7.0 | H0 3 = 2: p = 0.033, H0 3 = 1: p = 0.06, |
H0 2 = 1:p = 1.00 |