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Fig. 3 | Orphanet Journal of Rare Diseases

Fig. 3

From: Alpha-mannosidosis: correlation between phenotype, genotype and mutant MAN2B1 subcellular localisation

Fig. 3

Confocal fluorescent microscopy images showing the intracellular localisation of the novel MAN2B1 missense variants in transfected HeLa-cells. The first column of images shows methanol-fixed transfected HeLa-cells stained for MAN2B1 (green), the second column shows the same cells stained for the lysosomal marker LAMP1 (red) and the third column shows merged images with colocalized MAN2B1 and LAMP1 (yellow). a: MAN2B1 p.Asp102Asn; b: MAN2B1 p.Gly153Val; c: MAN2B1 p.Arg962His; d: WT. The WT was included as a positive control of lysosomal localization

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