Expression profiling of white sponge nevus by RNA sequencing revealed pathological pathways

Table 1 GSEA analysis of a normal subject

Number	Upregulated on normal	Size	ES	NES
1	DETECTION_OF_STIMULUS	27	−0.6574245	−1.8061078
2	G_PROTEIN_SIGNALING_COUPLED_TO_IP3_SECOND_MESSENGERPHOSPHOLIPASE_C_ACTIVATING	24	−0.6308761	−1.6817592
3	PHOSPHOINOSITIDE_MEDIATED_SIGNALING	27	−0.60555935	−1.6654842
4	POTASSIUM_CHANNEL_ACTIVITY	32	−0.56262994	−1.5977739
5	HYDROLASE_ACTIVITY_ACTING_ON_CARBON_NITROGEN_NOT_PEPTIDEBONDS	25	−0.5852488	−1.5726966
6	POTASSIUM_ION_TRANSPORT	36	−0.53710914	−1.5694768
7	CATION_CHANNEL_ACTIVITY	82	−0.46867418	−1.5630565
8	SUBSTRATE_SPECIFIC_CHANNEL_ACTIVITY	106	−0.44555083	−1.5522181
9	ANION_TRANSPORT	16	−0.6484232	−1.5312126
10	GATED_CHANNEL_ACTIVITY	86	−0.44908124	−1.5255814
11	HORMONE_METABOLIC_PROCESS	18	−0.61389524	−1.5086162
12	SULFOTRANSFERASE_ACTIVITY	18	−0.60654145	−1.4967437
13	ION_CHANNEL_ACTIVITY	101	−0.43095177	−1.4898388
14	HEMATOPOIETIN_INTERFERON_CLASSD200_DOMAIN_CYTOKINE_RECEPTOR_BINDING	20	−0.5910758	−1.4891092
15	CELL_CYCLE_PROCESS	107	−0.41814068	−1.4650342
16	VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY	44	−0.48482108	−1.463665
17	AXONOGENESIS	26	−0.54742056	−1.4614419
18	HEART_DEVELOPMENT	19	−0.5847264	−1.4440396
19	LIGAND_GATED_CHANNEL_ACTIVITY	30	−0.51191664	−1.4319984
20	NEUROTRANSMITTER_RECEPTOR_ACTIVITY	32	−0.500388	−1.4252495

ISSN: 1750-1172