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Table 1 Demographics and general phenylketonuria screening and management characteristics

From: Phenylketonuria screening and management in southeastern Europe – survey results from 11 countries

  Total pop. (millions) GDP per cap. in 2012 (USD) First year of PKU screening Screened / all nbs in 2012 Classic PKU incidence Phe screening cut-off (mg/dl) Age when screened (h) National PKU registry No. patients in the PKU registry Children/Adults care
Albania 2.83 9403 NI -/35,295 Unknown - - No - Nd
Bosnia – FBH (without Sarajevo Canton) 2.07 9392 2001(Tz) 2005 16,915a/16,790 1/29,998 (est.) 4 48–120 No - Ped/Ped
Bosnia – Rep. Srpska 1.33 9392 1986 (BL), 2007 9907/9978 1/34,817 (est.) 2.1–3 48–72 In prep. - Ped/Ped
Bosnia – Sarajevo Canton 0.44 9392 2006 5152/5167 Unknown 2.1 24 (96 if CS) No - Ped/Ped
Bulgaria 7.36 16,041 1979 62,496/69,121 1/28,370 b 3.3 72 Yes 74c Ped/Int
Croatia 4.28 20,961 1978 (Zg), 1986 41,606/41,700 1/12,000 d 4 72 Yes 194 Ped/Ped
Kosovo 1.74 8436 NI -/34,262 Unknown - - No - Nd
Macedonia 2.06 11,834 NI -/23752 Unknown - - No - Ped/Int
Moldova 3.50 4219 1989 36,654/39,641 1/7325e 3 >48 Yes 101 Gen/Gen
Montenegro 0.63 14,358 NI -/8156 Unknown - - No - Nd
Romania 18.91 18,063 2011 141,204/195,000 1/10,000 (est.) 3 48–72 Yes 40c Ped/Int
Serbia (without Vojvodina) 7.18 11,801 1983 52,094/49,325f 1/39,338 g 2 48–72 Yes 63 Ped/Ped
Slovenia 2.05 28,476 1979 21,888/21,938 1/10,000h 2.1–3 48–72 Yes 145 Ped/Ped
  1. BL only in region Banja Luka; cap capita; CS cesarean section; est. estimation; FBH Federation of Bosnia and Herzegovina; GDP gross domestic product; Gen geneticists; h hours; Int internists; nbs newborns; Nd no data available; NI not introduced yet; Ped pediatricians; Phe phenylalanine; PKU phenylketonuria; prep. preparation; Rep. Republic; Tz only in Tuzla Canton; Zg only in city Zagreb
  2. aNumber includes some newborns from Brcko District
  3. bKremensky et al, please see ref. [17]
  4. cBulgarian national PKU registry was established in the year 2000; Romanian national PKU registry was established in the year 2011. Both are including only patients diagnosed afterwards
  5. dKaracic et al, please see ref. [23]
  6. eHyperphenylalaninemias cumulatively; Published in: Boiciuc K, Usurelu N, Stratila M, Sacara V: Fenilcetonuria in Rešpublica Moldova – diagnosticul prin screening neonatal si analiza molecular genetic. In Patologa malformativa neonatal. Edited by Stamatin M, Stratulat P. Zilele Neonatologiei Moldave, Technopress; 2013:146–153
  7. fNumber of screened newborns includes some screening cards from Vojvodina and Montenegro
  8. gStojiljkovic et al, please see ref. [18]
  9. hGroselj et al, please see ref. [22]