Prevalence of pemphigus and pemphigoid autoantibodies in the general population

Table 2 Prevalence of pemphigus and pemphigoid autoantibodies in healthy blood donors

Antigen	IIFM positive* [n]	IIFM positive* [%]	ELISA**
Antigen	IIFM positive* [n]	IIFM positive* [%]	Negative [n]	Below diagnostic cut-off [n]	Above diagnostic cut-off (≥20 RU/ml) [n]
Dsg1^#	15	0.21 (0.11-0.32)	8	6	1
Dsg3^#	7	0.10 (0.03-0.17)	1	6	0
BP180-NC16A^§	37	0.52 (0.36-0.69)	2	19	16
BP230^#	3	0.04 (0.00-0.09)	1	2	0

*From a total of 7063 samples. Numbers in parentheses correspond to a 95 % confidence interval. This table contains double positives. **All IIF-positive samples were included (15 for Dsg1, 7 for Dsg3, 37 for BP180-NC16A, 3 for BP230). ^#Transfected HEK cells expressing recombinant antigen. ^§Purified spotted protein. Abbreviations used: IIFM, indirect immunofluorescence microscopy

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