Table 2 Comparison of clinical features of 81 patients with good or poor outcomes
From: Inflammatory myopathy with anti-signal recognition particle antibodies: case series of 100 patients
Good outcome | Poor outcome | p | |
|---|---|---|---|
(n = 59) | (n = 22) | ||
Females | 35 (59 %) | 16 (73 %) | 0.3 |
Age at disease onset ≤ 15 years | 1 (2 %) | 6 (27 %) | 0.0003 |
Disease progression > 12 months | 12 (20 %) | 8 (36 %) | 0.1 |
Clinical characteristics | |||
Legs predominantly than arms | 43 (73 %) | 16 (73 %) | 1.0 |
Severe limbs weakness | 31 (53 %) | 20 (91 %) | 0.001 |
Neck weakness | 37 (63 %) | 17 (77 %) | 0.2 |
Dysphagia | 20 (34 %) | 14 (63 %) | 0.02 |
Muscle atrophy | 32 (54 %) | 20 (91 %) | 0.002 |
Decreased deep tendon reflex | 28 (47 %) | 15 (68 %) | 0.1 |
Myalgia | 19 (32 %) | 7 (32 %) | 1.0 |
Interstitial lung disease | 12 (20 %) | 0 (0 %) | 0.02 |
Laboratory findings | |||
Creatine kinase (IU/L) | 6181 ± 4313 | 7079 ± 5263 | 0.5 |
Elevated C-reactive protein | 7 (12 %) | 8 (36 %) | 0.01 |
Anti-SRP54 antibody index | 1.4 ± 1.0 | 1.3 ± 1.1 | 0.8 |
Lymphocyte infiltration in histology | 11 (19 %) | 3 (14 %) | 0.6 |