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Table 1 Before and after ≥ M6 HU and bivariate analyses of biological parameter variations and %DRBC change

From: Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea

Parameter

Biological parameter values (mean ± SD)

Bivariate analysis

 

Before

After ≥ M6

p value

r

p value

%DRBCs

10.48 ± 8.75

6.18 ± 4.49

0.0003

  

%HbF

7.17 ± 4.13

17.45 ± 8.14

<0.0001

−0.080

0.556

Hb (g/dL)

9.04 ± 1.28

9.91 ± 1.67

<0.0001

−0.071

0.602

WBCs (G/L)

10.09 ± 2.54

7.10 ± 2.03

<0.0001

0.200

0.140

MCV (fl)

89.16 ± 8.04

108.69 ± 12.74

<0.0001

−0.059

0.665

MCHC (g/dL)

33.44 ± 1.23

33.48 ± 0.84

0.796

−0.022

0.874

MCH (pg)

29.84 ± 3.23

36.43 ± 4.64

<0.0001

−0.069

0.615

Reticulocytes (G/L)

244.92 ± 80.84

146.48 ± 64.99

<0.0001

0.238

0.077

Platelets (G/L)

396.41 ± 149.51

325.49 ± 106.09

0.0002

−0.069

0.614

Total bilirubin (μmol/L)

45.96 ± 26.76

35.64 ± 20.48

<0.0001

0.335

0.012

ALT (IU/L)

29.81 ± 16.22

26.89 ± 12.14

0.212

0.068

0.620

AST (IU/L)

44.04 ± 17.13

39.67 ± 16.26

0.149

0.311

0.020

LDH (IU/L)

433.02 ± 180.19

368.98 ± 139.66

0.0004

0.363

0.006

  1. Numerical data in bold indicate significant correlation with %DRBC decrease.