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Table 1 Before and after ≥ M6 HU and bivariate analyses of biological parameter variations and %DRBC change

From: Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea

Parameter Biological parameter values (mean ± SD) Bivariate analysis
  Before After ≥ M6 p value r p value
%DRBCs 10.48 ± 8.75 6.18 ± 4.49 0.0003   
%HbF 7.17 ± 4.13 17.45 ± 8.14 <0.0001 −0.080 0.556
Hb (g/dL) 9.04 ± 1.28 9.91 ± 1.67 <0.0001 −0.071 0.602
WBCs (G/L) 10.09 ± 2.54 7.10 ± 2.03 <0.0001 0.200 0.140
MCV (fl) 89.16 ± 8.04 108.69 ± 12.74 <0.0001 −0.059 0.665
MCHC (g/dL) 33.44 ± 1.23 33.48 ± 0.84 0.796 −0.022 0.874
MCH (pg) 29.84 ± 3.23 36.43 ± 4.64 <0.0001 −0.069 0.615
Reticulocytes (G/L) 244.92 ± 80.84 146.48 ± 64.99 <0.0001 0.238 0.077
Platelets (G/L) 396.41 ± 149.51 325.49 ± 106.09 0.0002 −0.069 0.614
Total bilirubin (μmol/L) 45.96 ± 26.76 35.64 ± 20.48 <0.0001 0.335 0.012
ALT (IU/L) 29.81 ± 16.22 26.89 ± 12.14 0.212 0.068 0.620
AST (IU/L) 44.04 ± 17.13 39.67 ± 16.26 0.149 0.311 0.020
LDH (IU/L) 433.02 ± 180.19 368.98 ± 139.66 0.0004 0.363 0.006
  1. Numerical data in bold indicate significant correlation with %DRBC decrease.