Figure 5

Urinary GAG levels over time by PAb status and genotype group. A) Urinary GAG levels over time by PAb status at the landmark point. Weeks 18 and 36, PAb+ vs PAb−, p < 0.001. Week 53, PAb+ vs PAb−, p = 0.002. B) Urinary GAG levels over time by genotype group. Week 18, CD/LR vs MS, p = 0.01. Week 36, CD/LR vs MS, p = 0.005. Week 53, CD/LR vs MS, p = 0.015. There were no other significant differences between groups. CD/LR, complete deletion/large rearrangement; FS/SSM, frameshift/splice site mutation; MS, missense mutation; PAb+, persistently antibody positive; PAb−, persistently antibody negative; uGAG, urinary glycosaminoglycan.