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Table 1 Age of onset in years, adjusted HR analysis for overall survival rates in patients with pemphigus vulgaris

From: Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study

Characteristic No (%) Deaths HR (95% CI) p-value
No (%)
Age of onset ≥ 65 years 27 (25.0%) 12 (70.6%) 9.37 (95%CI 3.3 – 26.65) <0.001
Age of onset < 65 years 81 (75.0%) 5 (29.4%)   
Gender (M) 46 (42.6%) 6 (35.3%) 0.73 (0.26 – 2.09) 0.561
Gender (F) 62 (57.4%) 11 (64.7%)   
Ethnicity (Romanian) 100 (92.6%) 16 (94.1%) 0.57 (0.07 – 4.12) 0.588
Ethnicity (Roma) 8 (7.4%) 1 (5.9%)   
Alcohol consumption (Yes) 20 (18.5%) 3 (17.7%) 1.52 (0.42 – 5.51) 0.524
Alcohol consumption (No) 88 (81.5%) 14 (82.3%)   
Smoking (Yes) 29 (26.9%) 2 (11.8%) 1.36 (0.29 – 6.33) 0.698
Smoking (No) 79 (73.1%) 15 (88.2%)   
Subtype of PV     
Mucocutaneous 80 (74.1%) 14 (82.3%) 2.60 (0.34 – 19.93) 0.357
Cutaneous 13 (12.0%) 1 (5.9%)   
Mucous 15 (13.9%) 2 (11.8%) 1.72 (0.16 – 18.97) 0.659
High blood pressure (Yes) 28 (25.9%) 6 (35.3%) 0.95 (0.35 – 2.60) 0.928
High blood pressure (No) 80 (74.1%) 11 (64.7%)   
Coronary heart disease (Yes) 11 (10.2%) 5 (29.4%) 3.04 (1.07 – 8.67) 0.037
Coronary heart disease (No) 97 (89.8%) 12 (70.6%)   
Heart failure (Yes) 4 (3.7%) 1 (5.9%) 0.63 (0.08 – 4.76) 0.651
Heart failure (No) 104 (96.3%) 16 (94.1%)   
Cardiac arrhythmia (Yes) 5 (4.6%) 3 (17.7%) 2.70 (0.75 – 9.59) 0.125
Cardiac arrhythmia (No) 103 (95.4%) 14 (82.3%)   
Diabetes mellitus (Yes) 8 (7.4%) 2 (11.8%) 0.91 (0.21 – 3.99) 0.898
Diabetes mellitus (No) 100 (92.6%) 15 (88.2%)   
Stroke (Yes) 5 (4.6%) 1 (5.9%) 1.08 (0.14 – 8.22) 0.944
Stroke (No) 103 (95.4%) 16 (94.1%)   
Depression (Yes) 5 (4.6%) 1 (5.9%) 2.09 (0.27 – 16.22) 0.480
Depression (No) 103 (95.4%) 16 (94.1%)   
Dental problems (Yes) 57 (52.8%) 7 (41.2%) 0.85 (0.32 – 2.28) 0.750
Dental problems (No) 51 (47.2%) 10 (58.8%)   
ESR ≥ 30 mm/hour 26 (42.6%) 9 (75.0%) 1.51 (0.37 – 6.20) 0.570
ESR < 30 mm/hour 35 (57.4%) 3 (25.0%)   
Steroids ≥ 1 mg/kg/day 15 (15.0%) 2 (14.3%) 0.88 (0.19 – 4.05) 0.868
Steroids < 1 mg/kg/day 85 (85.0%) 12 (85.7%)   
Anti-Dsg1 autoAbs ≥ 100 U/mL 45 (45.5%) 11 (64.7%) 1.98 (0.71 – 5.53) 0.195
Anti-Dsg1 autoAbs < 100 U/mL 54 (54.5%) 6 (35.3%)   
Anti-Dsg3 autoAbs ≥ 100 U/mL 71 (71.7%) 11 (64.7%) 0.60 (0.22 – 1.63) 0.314
Anti-Dsg3 autoAbs <100 U/mL 28 (28.3%) 6 (35.3%)