Stop criteria | Class of recommendation |
---|---|
Non-compliance > 50% of infusions | Class I |
Failure to attend regularly (according to local guidelines) at FU visits | Class I |
Persistent life threatening or severe infusion reactions that do not respond to prophylaxis, e.g. anaphylaxis | Class I |
Patient request | Class I |
End stage renal disease, without an option for renal transplantation, in combination with advanced heart failure (NYHA class IV) | Class IIA |
End stage FD or other comorbidities with a life expectancy of < 1 year | Class IIB |
Severe cognitive decline of any cause | Class IIB |
Lack of response for 1 year when the sole indication for ERT is neuropathic pain while receiving maximum supportive care* | Class IIB |
Criteria for not starting ERT | Class of recommendation |
Advanced cardiac disease with extensive fibrosis [37] if cardiac disease is the sole treatment indication† | Class I |
End stage renal disease, without an option for renal transplantation, in combination with advanced heart failure (NYHA class IV) | Class IIA |
End stage FD or other comorbidities with a life expectancy of < 1 year | Class IIB |
Severe cognitive decline of any cause | Class IIB |