Figure 2

The graph shows the frequency of clinical features in HHH syndrome. For Intellectual disability we identified two categories: mild (lQ/DQ50-69)/modarate (IQ/DQ35-49) [white bars], and serve (IQ/DQ < 35) [gray barsj. A similar classification was adopted for hepatopathy [mild/moderate up to 10×) or serve (>10×) increase of trans saminases] and coagulopathy [mild:nioderate individua coagulation factors 40%-70%, INP 1.5-2.0) or serve (individuaI coagulation factors <40%, INP > 2.0 or related clinical Manifestations) abnormalities of prothromibin time and INR).